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Biochemistry

Code:

BINF014

Sigla:

BQ

Áreas Científicas
Classificação	Área Científica
OFICIAL	Biotecnologia

Ocorrência: 2020/2021 - 1S

Ativa?	Yes
Unidade Responsável:	Biotecnologia
Curso/CE Responsável:	Undergraduate in Bioinformatics

Ciclos de Estudo/Cursos

Sigla	Nº de Estudantes	Plano de Estudos	Anos Curriculares	Créditos UCN	Créditos ECTS	Horas de Contacto	Horas Totais
BINF	27	Study Plan	2	-	4,5	52,5	121,5

Língua de trabalho

Portuguese

Objetivos

The objective of this curricular unit is the knowledge and understanding of the properties and structure of the foremost classes of biomolecules (sugars, lipids, proteins and nucleic acids), their interactions with the solvent water, and the mechanisms by which they react in a controlled manner in the context of the living cell.

Resultados de aprendizagem e competências

The student should be able to describe the structure and function of proteins, apply methods of isolation and characterization of protein, interpret enzyme kinetic parameters, understand the functions and chemical nature of diverse sugars and lipids, know the components and properties of biological membranes, the structure and characteristics of nucleic acid. He will know the role of ATP, NAD(P)H and FAD in the metabolism, and the major metabolic pathways, being capable of performing bioenergetics calculations.
The student should develop the capacity to relate and integrate all concepts so as to visualize the molecular functioning of the cell as a whole.

Modo de trabalho

Presencial

Programa

Chapter 1.Introduction to biochemistry. Biodiversity of living organisms vs biochemical uniformity; different types of cells and their característics. Biological functions in aqueous system

Chapter2. Biomolecules: aminoacids and peptides: properties; Properties, function and structure of proteins; methods of isolation, purification and quantification of proteins; Enzymes – reaction mechanism and kinetics; Structure and function of lipids, biological membranes – composition, function and transport systems. Nucleic acids and nucleotides – structure, properties, role. Genetic information flux – replication, transcription and translation. Recombinant DNA technology. Structure and function of sugars.

Chapter 3.Bioenergetics and metabolism: fundaments of bioenergetic, metabolic pathway, catabolism and anabolism. Glycolisis, tricarcoxylic acid cycle, pentose phosphate pathway, respiratory chain, betaoxidation of fatty acids, degradation of amino acids for energy gain, urea cycle.

Bibliografia Obrigatória

coord. Alexandre Quintas, Ana Ponces Freire, Manuel J. Halpern; Bioquímica : organização molecular da vida, Lidel, 2008. ISBN: 978-972-757-431-5
Jeremy M. Berg, John L. Tymoczko, Lubert Stryer; Biochemistry, W. H. Freeman and Company, 2007. ISBN: 978-0-7167-8724-2
David L. Nelson, Michael M. Cox; Lehninger principles of biochemistry, W. H. Freeman and Company, 2008. ISBN: 0-7167-7108-X (5th ed.)
Keith Wilson, John Walker; Principles and techniques of biochemistry and molecular biology, Cambridge University Press, 2010. ISBN: 978-0-521-73167-6
David L. Nelson, Michael M. Cox; Lehninger principles of biochemistry, W. H. Freeman and Company, 2005. ISBN: 0-7167-4339-6

Bibliografia Complementar

coord. Manuel Júdice Halpern; Bioquímica, Lidel, 1997. ISBN: 972-757-042-9
Richard I. Gumport, FRank H. Deis, Nancy Counts Gerber ; Roger E. Koeppe; Student companion to accompany biochemistry : sixth edition, W. H. Freeman and Company, 2006. ISBN: 978-0-7167-7067-1
Paul F. Cook, W. W. Cleland; Enzyme kinetics and mechanism, Garland Science, , 2007. ISBN: 978-0-8153-4140-6
David Hames, Nigel Hooper; Instant Notes: Biochemistry, Taylor & Francis, 2005. ISBN: 0-4153-6778-6

Métodos de ensino e atividades de aprendizagem

The theoretical component will be presented in expository mode using Powerpoint slides. The integration of concepts will be carried out through the resolution of practical exercises and case studies, interspersed with the expository method whenever possible.

Tipo de avaliação

Distributed evaluation with final exam

Componentes de Avaliação

Designation	Peso (%)
Teste	80,00
Trabalho escrito	20,00
Total:	100,00

Componentes de Ocupação

Designation	Tempo (Horas)
Estudo autónomo	45,00
Frequência das aulas	45,00
Trabalho de investigação	5,00
Trabalho escrito	26,50
Total:	121,50

Obtenção de frequência

Not applicable.

Fórmula de cálculo da classificação final

Continuous Assessment:

FC= 80 % (average of 3 tests) + 20% (average of case-studies)

Exam:

FC= 100 % Exam OR 80% Exam + 20% (average of case-studies) – best classification of 2 options.

Provas e trabalhos especiais

The case-studies are small works of knowledge application, to be elaborated in groups or individually. Each case-study is presented in class, contextualized in the contents under study and a deadline appropriate to the required effort is given (extendable whenever students (from any of the courses) report that there is an overlap with situations of great intensity of moments of evaluation of other UCs).

Avaliação especial (TE, DA, ...)

There is no provision for any special assessment regime, not included in those already provided for in the Regulation. However, for students who either with special statutes or in the pandemic context do not attend classes with case-study presentations, a statement will be made available to them.

Observações

In the current academic year, the typology of classes was partially modified, with the majority of theoretical contents being exposed in a class common to all students – indicated as theoretical; and the resolution of exercises and practical application activities prevailing in the 2nd class of the week – indicated as TP, so that the latter can be taught in person (or mixed) if the physical conditions allow it.