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Metabolism and Regulation

Code:

BINF024

Sigla:

MR

Áreas Científicas
Classificação	Área Científica
OFICIAL	Biotecnologia

Ocorrência: 2018/2019 - 2S

Ativa?	Yes
Unidade Responsável:	Biotecnologia
Curso/CE Responsável:	Undergraduate in Bioinformatics

Ciclos de Estudo/Cursos

Sigla	Nº de Estudantes	Plano de Estudos	Anos Curriculares	Créditos UCN	Créditos ECTS	Horas de Contacto	Horas Totais
BINF	19	Study Plan	2	-	5	67,5	135

Língua de trabalho

Portuguese

Objetivos

The goals of this UC are to have the students recognize and understand that the various cellular processes are organized and use recurring motifs, and that metabolism has evolved various processes in order to maintain homeostasis. Building on the Bioquímica UC, metabolic pathways will be studied and an introduction to their mathematical description is included. An introduction to drug action and metabolism is also included in order to show that drugs can be looked at as metabolic modulators. Identification of the organizing motifs allows students to develop an analysis of metabolism that can be easily transferred between systems; this is strengthened by the mathematical analysis of metabolism, needed in the 5th semester.

Resultados de aprendizagem e competências

.

Modo de trabalho

Presencial

Programa

1. Metabolism, the metabolic map and recurring motifs.
2. Fundamental pathways of the cell – the example of glycolysis and its associated and parallel pathways.
3. Regulation as a tool to maintain homeostasis.
4. Fundamental mechanisms of regulation –enzyme activity; gene expression.
5. Recurring motifs in regulation – feed-back and feed-forward; enzyme covalent modification; channeling;
futile cycles; switches; signaling; cascading.
6. Metabolic networks – mass action and power laws; mass balance; steady state.
7. Xenobiotic metabolism – biotransformation of xenobiotics; introduction to pharmacokinetics – LADME
scheme vs. normal intracellular processes; non-compartmental and compartmental models; conserved
mechanisms of drug action –targets and mode of action. Drugs as metabolic regulators.
8. Metabolic Control Analysis – Flux and response coefficients; sensitivity and elasticity.
9. Intracellular vs. Extracellular communication – first and second messengers; receptors.

Bibliografia Obrigatória

Fell, D.; Understanding the Control of Metabolism
Hardie, D.G.; Biochemical Messengers: Hormones, Neurotransmitters and Growth Factors, Springer. ISBN: 978-9-401-05376-1
Heinrich, R., Schuster, S.; The Regulation of Cellular Systems , Springer. ISBN: 978-0-412-03261-5
Nelson, D.L., Cox, M.M.; Lehninger Principles of Biochemistry , W.H. Freeman. ISBN: 978-1-429- 23414-6
Rosenbaum, S. E.; Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations, Wiley. ISBN: 978-0-470-56906-1
Salway, J. G.; Metabolism at a Glance, Wiley-Blackwell. ISBN: 978-1-405-10716-7

Métodos de ensino e atividades de aprendizagem

3 h weekly lectures or exercise classes. Topics will be presented in lectures and exercise classes are
organized so that students can, when appropriate, practice introductory exercises approaching metabolic network topics.

Tipo de avaliação

Distributed evaluation with final exam

Componentes de Avaliação

Designation	Peso (%)
Teste	70,00
Trabalho escrito	30,00
Total:	100,00

Fórmula de cálculo da classificação final

Continuous assessment:

0,35x Test 1 + 0,35 x Test 2 +0,15 x Work 1 + 0,15 x Work 2

Exam:

1,00 x Exam

0,70 x Exam + 0,15 x 0,15 x Work 1 + 0,15 x Work 2