Autenticação

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Functional genomics and bioinformatics

Code:

MEBQB12

Sigla:

GFB

Áreas Científicas
Classificação	Área Científica
OFICIAL	Biotecnologia

Ocorrência: 2019/2020 - 1S

Ativa?	Yes
Página Web:	https://moodle.ips.pt/1920/course/view.php?id=2291
Unidade Responsável:	Biotecnologia
Curso/CE Responsável:	Master in Biological and Chemical Engineering

Ciclos de Estudo/Cursos

Sigla	Nº de Estudantes	Plano de Estudos	Anos Curriculares	Créditos UCN	Créditos ECTS	Horas de Contacto	Horas Totais
MEBQ	12	Study Plan	2	-	5	45	135

Língua de trabalho

Portuguese

Objetivos

This UC has as main objective to provide students with an integrated view of the organizational structure and the functioning of genes and genomes, taking into account technological advances in the methods of sequencing, annotation and analysis of their functioning. 

Resultados de aprendizagem e competências

Students should acquire knowledge about bioinformatics tools and methodologies for search and analysis of sequences and their potential to predict function, as well as analysis of gene expression data at the level of RNA and proteins.

Modo de trabalho

Presencial

Pré-requisitos (conhecimentos prévios) e co-requisitos (conhecimentos simultâneos)

No

Programa

1-Organizational structure of genomes; Methods for genome sequencing, genome analysis and annotation. 2-Evolution of genomes and molecular phylogeny. Comparative Genomics. Definition of orthologs and paralogs genes. 3-Analysis of the genome-wide gene expression by proteomics and transcriptomics approach. 4-Functional Genomics. Metabolomics, RNomics, metagenomics and other omics. 5-Applications of bioinformatics in genomics. Algorithms for sequence alignment: single and multiple alignments; motif-search algorithms: motif representation and search systems available on the web. 6-Biotechnological applications. Laboratorial practical classes: Use of bioinformatic tools to perform sequence alignments and sequence database searches (BLAST e Clustal), phylogenetic analysis and cladograms, motif search and prediction of gene function, prediction of protein structure, interpretation of biological significance of genome-scale data.

Bibliografia Obrigatória

C.W. Sensen; Handbook of Genome Research, vol. I e vol.II, 2005. ISBN: ISBN 3-527-31348-6
T. A. Brown; Gene Cloning and DNA Analysis, An Introduction, 6.ª edição, Wiley-Blackwell, 2010
A.D.Baxevanis, B.F.F.Ouellette,; Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins, 3.ª edição,WileyInterscience, 2005. ISBN: ISBN 978-0-471-38391-8
M. Borodovsky, S.Ekisheva; Problems and Solutions in Biological Sequence Analysis, Cambridge University Press, 2007. ISBN: ISBN 978-0-521-61230-2
Mount, D.; Bioinformatics: Sequence and Genome Analysis, 2.ª edição, Cold Spring Harbor Laboratory Press, 2004. ISBN: 978-0-879-69712-9
Durbin, R., Eddy, S. R., Krogh, A., Mitchison G.; Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids, Cambridge University Press, 2004. ISBN: 978-0-521-62971-3

Métodos de ensino e atividades de aprendizagem

The curricular unit is taught using expository and demonstrative methods with computer support PowerPoint presentations. The curricular unit consists of a theoretical and practical component in which students discuss current topics in the field of structural, evolutionary and functional genomics

Tipo de avaliação

Distributed evaluation with final exam

Componentes de Avaliação

Designation	Peso (%)
Participação presencial	10,00
Trabalho escrito	90,00
Total:	100,00

Componentes de Ocupação

Designation	Tempo (Horas)
Estudo autónomo	90,00
Frequência das aulas	45,00
Total:	135,00

Obtenção de frequência

No mandatory assistance.

Fórmula de cálculo da classificação final

Continuous Assessment: (40% Trab1) + (40% Trab2) + (10% Trab 3) + (10% Classes)

1st / 2nd Season Assessement: 100% Exam