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Cell and Molecular Biology

Code:

BIOT154

Sigla:

BMC

Áreas Científicas
Classificação	Área Científica
OFICIAL	Biotecnologia

Ocorrência: 2022/2023 - 2S

Ativa?	Yes
Unidade Responsável:	Departamento de Engenharia Química e Biológica
Curso/CE Responsável:	Undergraduate in Biotechnology

Ciclos de Estudo/Cursos

Sigla	Nº de Estudantes	Plano de Estudos	Anos Curriculares	Créditos UCN	Créditos ECTS	Horas de Contacto	Horas Totais
BIOT	65	Study Plan	2	-	5	67,5	135

Língua de trabalho

Portuguese

Objetivos

The objective of this curricular unit is to increase the knowledge about the basic functional unit of all living beings – the cell, in terms of its composition, dynamic and functioning.

Resultados de aprendizagem e competências

The students should know and comprehend molecular and cellular events intrinsic to the functioning, regulation and cellular differentiation, and they should acquire the capacity to have a global perspective of the working of cells and consequently of living organism. It is intended that the students acquire knowledge and be able to apply basic experimental methodologies of molecular biology.

Modo de trabalho

Presencial

Programa

1. Biomembranes: transport systems, signal transduction and membrane receptors.


2. Overview of the structure and function of proteins


3. Physico-chemical structure of nucleic acids. Expression of the genetic information, RNA synthesis (transcription) and processing. Protein synthesis (translation). Maintenance of the genetic information. DNA replication and repair. Recombination. Mitosis and meiosis. Molecular mechanisms of homologous recombination. Detection, tipes and effects of mutations.


4. Mobile genetic elements (virus, transposons and plasmids). Recombinant DNA technology. Regulation of gene expression.

1. Genomic organization, gene and non-coding sequences, chromosomal structure and morphology


2. Molecular control of the cell cycle. Cell division. stem cell lines and formation of gametes. Regulatory process of programmed cell death, necroses and apoptosis.

Bibliografia Obrigatória

coord.Carlos Azevedo, Cláudio E. Sunkel; Biologia celular e molecular, Lidel , 2012. ISBN: ISBN 978-972-757-692-0
Bruce Alberts ...[et al.]; Molecular biology of the cell, Garland Science, , 2008. ISBN: ISBN 0-8153-4106-7 (5th ed.)
David Sadava ...[et al.]; Life : the science of biology, Sinauer Associates, 2014. ISBN: ISBN 978-1-4641-3639-9 (10th ed)
T. A Brown; Gene Cloning and DNA Analysis : An Introduction, John wiley and sons ltd, 2016. ISBN: 9781119072560
Jeff Hardin, Gregory Bertoni, Lewis J. Kleinsmith; Becker's world of the cell, Pearson, 2012. ISBN: ISBN 0-321-70978-0. - ISBN 978-0-321-70978-3

Bibliografia Complementar

Harvey Lodish...[et al.]; Molecular cell biology, W.H. Freeman, cop., 2008. ISBN: ISBN 978-0-7167-6017 (6th ed)
Michael R. Green, Joseph sambrook; Molecular cloning : a laboratory manual, CSH Press, 2012. ISBN: ISBN 978-193611342-2 (4 th ed)

Métodos de ensino e atividades de aprendizagem

This curricular unit is organized in two parts, a theoretical component and a practical one. Presentation of the theoretical content will be done with the help of powerpoint support. The syllabus contents will be presented to the students, to help him attain a profound knowledge of functioning of a cell. The practical component will allow the students to acquire basic competencies to do and analyze the results of laboratory procedures in the context of molecular biology. In this component, series of practical exercises will be resolved, that contextualize with relevant aspects of laboratory and real life situations. In terms of evaluation, a higher weight is given to the understanding of the syllabus contents, being the practical application accounted for the grade.

Software

Benchling
Lasergene

Palavras Chave

Natural sciences > Biological sciences > Biology > Molecular biology
Natural sciences > Biological sciences > Biology > Cell biology

Tipo de avaliação

Distributed evaluation with final exam

Componentes de Avaliação

Designation	Peso (%)
Apresentação/discussão de um trabalho científico	10,00
Teste	85,00
Participação presencial	5,00
Total:	100,00

Componentes de Ocupação

Designation	Tempo (Horas)
Apresentação/discussão de um trabalho científico	15,00
Estudo autónomo	60,00
Frequência das aulas	60,00
Total:	135,00

Obtenção de frequência

Attending classes (maximum of 20% of unjustified absences) is required as access condition to the continuous assessment regime. 

Fórmula de cálculo da classificação final

Continuous assessment: 
FG= 85% (Test1 +Test2)/2 + 10% Group Work (Molec. Biol.) + 5% (Participation in classroom activities)

Exam (1st and 2nd) 
FG = 100 % Exam OR  Exam + components of continuous assessment (90 % Exam + 10% Work )

Special Exams:
FG = 100 % Exam OR  Exam + components of continuous assessment (90 % Exam + 10% Work )

Observations: For final grades equal to or greater than 16, a confirmatory oral test may be required, and in case of non-attendance the final grade will be 15.