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Biochemistry

Code:

BINF014

Sigla:

BQ

Áreas Científicas
Classificação	Área Científica
OFICIAL	Biotecnologia

Ocorrência: 2023/2024 - 1S

Ativa?	Yes
Página Web:	https://moodle.ips.pt/2324/course/view.php?id=548
Unidade Responsável:	Departamento de Engenharia Química e Biológica
Curso/CE Responsável:	Undergraduate in Bioinformatics

Ciclos de Estudo/Cursos

Sigla	Nº de Estudantes	Plano de Estudos	Anos Curriculares	Créditos UCN	Créditos ECTS	Horas de Contacto	Horas Totais
BINF	23	Study Plan	2	-	4,5	52,5	121,5

Língua de trabalho

Portuguese

Objetivos

The objective of this curricular unit is the knowledge and understanding of the properties and structure of the foremost classes of biomolecules (sugars, lipids, proteins and nucleic acids), their interactions with the solvent water, and the mechanisms by which they react in a controlled manner in the context of the living cell.

Resultados de aprendizagem e competências

The student should be able to describe the structure and function of proteins, apply methods of isolation and characterization of protein, interpret enzyme kinetic parameters, understand the functions and chemical nature of diverse sugars and lipids, know the components and properties of biological membranes, the structure and characteristics of nucleic acid. He will know the role of ATP, NAD(P)H and FAD in the metabolism, and the major metabolic pathways, being capable of performing bioenergetics calculations.
The student should develop the capacity to relate and integrate all concepts so as to visualize the molecular functioning of the cell as a whole.

Modo de trabalho

Presencial

Programa

Chapter 1.Introduction to biochemistry. Biodiversity of living organisms vs biochemical uniformity; different types of cells and their característics. Biological functions in aqueous system

Chapter2. Biomolecules: aminoacids and peptides: properties; Properties, function and structure of proteins; methods of isolation, purification and quantification of proteins; Enzymes – reaction mechanism and kinetics; Structure and function of lipids, biological membranes – composition, function and transport systems. Nucleic acids and nucleotides – structure, properties, role. Genetic information flux – replication, transcription and translation. Recombinant DNA technology. Structure and function of sugars.

Chapter 3.Bioenergetics and metabolism: fundaments of bioenergetic, metabolic pathway, catabolism and anabolism. Glycolisis, tricarcoxylic acid cycle, pentose phosphate pathway, respiratory chain, betaoxidation of fatty acids, degradation of amino acids for energy gain, urea cycle.

Bibliografia Obrigatória

coord. Alexandre Quintas, Ana Ponces Freire, Manuel J. Halpern; Bioquímica : organização molecular da vida, Lidel, 2008. ISBN: 978-972-757-431-5
Jeremy M. Berg, John L. Tymoczko, Lubert Stryer; Biochemistry, W. H. Freeman and Company, 2007. ISBN: 978-0-7167-8724-2
David L. Nelson, Michael M. Cox; Lehninger principles of biochemistry, W. H. Freeman and Company, 2008. ISBN: 0-7167-7108-X (5th ed.)
Keith Wilson, John Walker; Principles and techniques of biochemistry and molecular biology, Cambridge University Press, 2010. ISBN: 978-0-521-73167-6
David L. Nelson, Michael M. Cox; Lehninger principles of biochemistry, W. H. Freeman and Company, 2005. ISBN: 0-7167-4339-6

Bibliografia Complementar

coord. Manuel Júdice Halpern; Bioquímica, Lidel, 1997. ISBN: 972-757-042-9
Richard I. Gumport, FRank H. Deis, Nancy Counts Gerber ; Roger E. Koeppe; Student companion to accompany biochemistry : sixth edition, W. H. Freeman and Company, 2006. ISBN: 978-0-7167-7067-1
Paul F. Cook, W. W. Cleland; Enzyme kinetics and mechanism, Garland Science, , 2007. ISBN: 978-0-8153-4140-6
David Hames, Nigel Hooper; Instant Notes: Biochemistry, Taylor & Francis, 2005. ISBN: 0-4153-6778-6

Métodos de ensino e atividades de aprendizagem

The theoretical component will be presented in expository mode using Powerpoint slides. The integration of concepts will be carried out through the resolution of practical exercises and case studies, interspersed with the expository method whenever possible.

Palavras Chave

Physical sciences > Chemistry > Biochemistry
Physical sciences > Chemistry > Biochemistry > Enzimology
Physical sciences > Chemistry > Biochemistry > Metabolism
Technological sciences > Technology > Biotecnology > Downstream processing
Technological sciences > Technology > Chemical technology > Biochemical technology

Tipo de avaliação

Distributed evaluation with final exam

Componentes de Avaliação

Designation	Peso (%)
Teste	80,00
Participação presencial	5,00
Trabalho escrito	15,00
Total:	100,00

Componentes de Ocupação

Designation	Tempo (Horas)
Estudo autónomo	56,50
Frequência das aulas	45,00
Trabalho de investigação	5,00
Trabalho escrito	15,00
Total:	121,50

Obtenção de frequência

Non applicable.

Fórmula de cálculo da classificação final

Continuous Assessment:

FC= 80% (average of 3 tests) + 15%  (case studies) + 5% (presential participation)
Minimum classification of 9.0 for average of testes.

Exam:

FC= 100 % Exam OR 80% Exam + 15%  (case studies) + 5% (presential participation) OR 85% Exam + 15%  (case studies) – best classification of 2 options.

Minimum classification of 9.0 for exam.

Provas e trabalhos especiais

The presential participation is evaluated as active presence in class.

Case-studies are the realization of small case-studies and/or small works of knowledge application, to be elaborated in groups or individually. Each case-study is presented in class, contextualized in the contents under study and a deadline appropriate to the required effort is given (extendable whenever students (from any of the courses) report that there is an overlap with situations of great intensity of moments of evaluation of other UCs).

Avaliação especial (TE, DA, ...)

There is no provision for any special assessment regime, not included in those already provided for in the Regulation.
For working-students, unable to attend classes (participation) and deliver the case studies, the continuous evaluation may be done solely by average of tests.