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Cellular and Molecular Biology

Code:

LTB21002

Sigla:

BCM

Áreas Científicas
Classificação	Área Científica
OFICIAL	Ciências Biomédicas e da Vida

Ocorrência: 2023/2024 - 1S

Ativa?	Yes
Unidade Responsável:	Departamento de Sistemas e Informática
Curso/CE Responsável:

Ciclos de Estudo/Cursos

Sigla	Nº de Estudantes	Plano de Estudos	Anos Curriculares	Créditos UCN	Créditos ECTS	Horas de Contacto	Horas Totais
LTB	38	Plano de Estudos	2	-	6	60	162

Língua de trabalho

Portuguese - Suitable for English-speaking students

Objetivos

The aim of the course is to enable students to acquire skills in cell and molecular biology that allow them to act as biomedical engineers in the development of support structures for research and clinical testing, processing, and interpretation of biological signals in the area of cellular and molecular biology. The program of course is organized as a journey into the cell focusing on processes of cell division, replication, transcription, and translation of nucleic acids. Special focus is given to the failures of vital physiological processes that correlate with diseases. Also, the regulatory processes must be understood by the students. 

Resultados de aprendizagem e competências

It is intended that students acquire skills in the technologies routinly used in molecular biology allowing them to develop new technologies applied to cellular and molecular biology in different areas, particularly in health, biomedical engineering, forensic toxicology and research.

Modo de trabalho

Presencial

Programa

Cell Biology Module
1. Cellular and Molecular Biology and Biomedical Engineering. Perspectives in the century XXI. 2. Cell hierarchy.
3 . Cellular structures: prions, viruses, prokaryotes, and eukaryotes
4 . Cell membrane.
5. Cytoskeleton and organelles. The extracellular matrix
6. Proteins and membrane transport systems: gap junctions in the inner ear and relationship to biomedicine - cochlear implants
7. Cellular compartments and molecular synchrony
8. Nucleic acids. Regulation of gene transcription. The healing process. Apoptosis
9. Cell cycle: regulation and concept of tumor
10. Prokaryotes cells
11 . Notions of phage therapy

Molecular Biology Module
1. Central Dogma of Molecular Biology and prions. The non-replicating protein
2 . Processing of proteins as a means of regulating gene
3 . Methylation and physiological processes such as phosphorylation homeostasis
4 . Mutations
5 . Restriction enzymes
6. Eletroforese
7. PCR and cloning
8. DNA Sequencing
9. Biotechnological applications with plasmids

Bibliografia Obrigatória

AZEVEDO, Carlos; Biologia Celular e Molecular
BAYNES; Bioquímica Médica
LEWIS, Ricki; Human genetics, concepts and applications
AVILA, Vernon; Biology –Investigating Life on Earth
LODISH, Harvey et al; Molecular Cell Biology
McKEE, Trudy; McKEE, James; Biochemistry: the molecular basis of life
QUINTAS, Alexandre, PONCES FREIRE, Ana, HALPERN, Manuel; Bioquimica: Organização molecular da vida. 1a Ed. Lisboa
STANSFIELD, William; COLOMÉ, Jaime, CANO, Raúl; Biologia Molecular e Celular – Teoria e Exercícios

Métodos de ensino e atividades de aprendizagem

In this course, the syllabus are organized into two semi-autonomous modules, which are related to the learning methodologies and with the organization of semester activities. There are flexibility in teaching practices and organization, allowing a more effective learning process of students since they are focus on the learning process, assuming the management for the development of their knowledge and skills. Moreover, the method implies that expository-participatory students carry out previously some research for better discuss topics. Thus, they should become proactive and not just knowing the contents, but also to be able to discuss the contents and even be able to propose developments of new laboratory procedures of molecular tests.

Tipo de avaliação

Evaluation with final exam

Componentes de Avaliação

Designation	Peso (%)
Exame	100,00
Total:	100,00

Componentes de Ocupação

Designation	Tempo (Horas)
Estudo autónomo	102,00
Frequência das aulas	60,00
Total:	162,00

Obtenção de frequência

Continuous evaluation with 2 intermediate tests or final exam

Fórmula de cálculo da classificação final

average of both tests(50% each) or final exam (100%)