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Separation Processes IB

Code:

BIOT153

Sigla:

PS IB

Áreas Científicas
Classificação	Área Científica
OFICIAL	Processos em Engenharia Química e Biológica

Ocorrência: 2023/2024 - 2S

Ativa?	Yes
Unidade Responsável:	Departamento de Engenharia Química e Biológica
Curso/CE Responsável:	Undergraduate in Biotechnology

Ciclos de Estudo/Cursos

Sigla	Nº de Estudantes	Plano de Estudos	Anos Curriculares	Créditos UCN	Créditos ECTS	Horas de Contacto	Horas Totais
BIOT	67	Study Plan	2	-	4,5	52,5	121,5

Língua de trabalho

Portuguese - Suitable for English-speaking students

Objetivos

The curricular unit of Separation Processes IB aims to provide unit operations of separation/purification used in biologic and related industries, providing students with the knowledge to design separation equipment.

Resultados de aprendizagem e competências

Competences of the students:
- Identify the basic principles of the separation processes.
- Choose the most appropriate processes for a given separation.
- Design separation equipment and assess the influence of operating conditions in the separation.

Modo de trabalho

Presencial

Programa

1. Introduction: Stages of a separation process and properties of biomolecules.
2. Cell rupture: Rupture Methods - Physical, Chemical and Enzymatic Methods, and Osmotic Shock.
3. Protein Precipitation: Methods - Addition of salts, pH control in isoelectric point, addition of non-ionic polymers, addition of solvents, addition of polyelectrolytes and addition of metal ions.
4. Solvent extraction: Extraction with organic solvents or supercritical fluids.
5. Gravitational sedimentation. Sedimentation velocity; Stokes Law; Design of sedimentation tanks.
6. Fluidization: Minimum speed of fluidization.
7. Centrifuging. Stokes law applied, equivalent settling area, types of centrifuges. Equations for centrifuges design.
8. Concentration of product: Drying and freeze drying.

Bibliografia Obrigatória

Coulson, J.M., Richardson, J.F; Chemical Engineering, Pergamon Press, 1985
Ladisch, M.R.; Bioseparations Engineering: Principles, Practice, and Economics, John Wiley & Sons, 2001
Seader, J.D., Henley, E.J.; Separation Processes Principles, John Wiley & Sons, 1998

Bibliografia Complementar

Betler, P.A., Cussler, A.L., Hu, W.-S.; Bioseparations: Downstream Processing for Biotechnology, John Wiley & Sons, 1988
Goldberg, E.; Handbook of Downstream Processing, Blackie Academic & Professional, 1997
Harrison, R., Todd, P., Rudge, S., Petrides, D.; Bioseparations Science and Engineering, Oxford University Press, 2003
Doran, P.; Bioprocess Engineering Principles, Academic Press, 2003
Forciniti, D.; Industrial Bioseparations: Principles and Practice, Wiley-Blackwell, 2007

Métodos de ensino e atividades de aprendizagem

Theoretical material will be presented, to promote the involvement and participation of all students, developing their reasoning skills and stimulating their critical thinking. Materials about the subjects lectured will be available for consultations on Moodle. It will be expected some guided technical visits allowing for the consolidation of the themes taught. At any time students can contact the professor via the Moodle platform.
The evaluation consists of 20% for the presentation/discussion of a scientific work and 80% for two tests or for the exam.

Tipo de avaliação

Distributed evaluation with final exam

Componentes de Avaliação

Designation	Peso (%)
Apresentação/discussão de um trabalho científico	20,00
Teste	80,00
Total:	100,00

Componentes de Ocupação

Designation	Tempo (Horas)
Apresentação/discussão de um trabalho científico	12,00
Estudo autónomo	64,50
Frequência das aulas	45,00
Total:	121,50

Obtenção de frequência

Not Applicable.

Fórmula de cálculo da classificação final

Continuous Evaluation:
FG=40% Test 1 + 40% Test 2 + 20% Presentation/discussion of a scientific work.

Minimum grade of 9.5 points in the weighted average of the tests.

Exam Evaluation (all seasons):
FG=100% Exam or 80% Exam + 20% Presentation/discussion of a scientific work – the best of the two options will be applied.

Minimum exam grade is 9.5 points.

- The student who signs the work and does not appear in its oral presentation/discussion, can be assigned a null classification in that presentation (weight of 50% in the final classification of the work). A different classification may be given to students in the same group based on the commitment shown, the quality of the oral presentation and the domain of the theme.

- The two tests and the presentation/discussion of a scientific work are mandatory as a condition of continuous assessment.