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Biological Reactors B

Code:

BIOT160

Sigla:

RB B

Áreas Científicas
Classificação	Área Científica
OFICIAL	Processos em Engenharia Química e Biológica

Ocorrência: 2022/2023 - 1S

Ativa?	Yes
Unidade Responsável:	Departamento de Engenharia Química e Biológica
Curso/CE Responsável:	Undergraduate in Biotechnology

Ciclos de Estudo/Cursos

Sigla	Nº de Estudantes	Plano de Estudos	Anos Curriculares	Créditos UCN	Créditos ECTS	Horas de Contacto	Horas Totais
BIOT	61	Study Plan	3	-	5,5	75	148,5

Língua de trabalho

Portuguese
Obs.: Reatores Biológicos B

Objetivos

The purpose of this curricular unit is in-depth knowledge of the operation mode of the various biological reactors, allowing the study of the mass transfer phenomena and design of agitation systems in fermentation broths. It is thus intended that students acquire knowledge about: the various operation modes of biological reactors and application of mass and energy balances for each type of reactor, the phenomena underlying the mixing and stirring of fermentation broths, sterilization and sizing criteria.

Resultados de aprendizagem e competências

This UC aims to approach the concepts necessary for the design and scaling of biological reactors.

Modo de trabalho

Presencial

Pré-requisitos (conhecimentos prévios) e co-requisitos (conhecimentos simultâneos)

No

Programa

Chapter 1: Comparison of chemical reactors with biological reactors. Key factors for the design of bioreactors.
Chapter 2: Microbial Kinetics; mass balance equations. Yield of a reaction and its determination. Classification of products. Inhibition of cell growth by the substrate and product.
Chapter 3: Operation Mode models for general CSTR; batch reactors and a bio-reactor working in semi-continuous mode.
Chapter 4: Oxygen Transfer in cell culture.
Chapter 5: Mixing and agitation. Bioreactors without mechanical agitation.
Chapter 6: Heat transfer in bioreactors.
Chap 7: Sterilization of fermentation media by heat in discontinuous and continuous mode. Air filtration.
Chapter 8: Criteria for bio-reactor scale-up.
Chapter 9: Examples of application of bio-reactors.

Bibliografia Obrigatória

M. Manuela da Fonseca e José A. Teixeira; Reactores Biológicos , Lidel, 2007. ISBN: ISBN-10:972-757-366-5
P. Doran; Bioprocess Engineering Principles, Acad. Press, 1995

Bibliografia Complementar

N. Lima, M. Mota; Biotecnologia, Fundamentos e Aplicações, Lidel, 2003

Métodos de ensino e atividades de aprendizagem

The lecture method-with student intervention, adopted for the lectures is appropriate for the presentation of the content covered in the curricular unit. The exercises solved in practical classes serve to help understand some concepts that may be difficult to understand in the  theoretical exposition. The written tests during the semester allow students to consolidate the knowledge acquired in stages during the course classes. In addition, it is also intended to foster critical thinking and reflection, so classes are taught in the form of a conversation with students.

Palavras Chave

Technological sciences > Technology > Biotecnology
Technological sciences > Technology > Nanotechonology > Nanodevices
Natural sciences > Biological sciences > Biological engineering > Genetic engineering

Tipo de avaliação

Distributed evaluation with final exam

Componentes de Avaliação

Designation	Peso (%)
Participação presencial	5,00
Teste	75,00
Trabalho escrito	20,00
Total:	100,00

Componentes de Ocupação

Designation	Tempo (Horas)
Estudo autónomo	66,00
Frequência das aulas	67,50
Trabalho de investigação	5,00
Trabalho escrito	10,00
Total:	148,50

Obtenção de frequência

Attendance is not mandatory.

Fórmula de cálculo da classificação final

Continuous Assessment: 75% x average of the 2 tests + 20% Group Work+ 5% Assessment in classroom

Assessment 1st / 2nd season and Special Season: 80% x Exam + 20% Group work OR 100% Exam

Melhoria de classificação

Exam 100%

Observações

Within the scope of continuous assessment, the student will be able to do group work on applications of bioreactors, selected from a set of proposed themes. These will include application of bioreactors for: animal cell culture, plant cell culture, production of recombinant proteins, production of antibiotics, production of baker's yeast, production of beer, microalgae culture, anaerobic digestion, aerobic waste treatment. Other applications may also be included if they are considered relevant and in line with the main objective proposed.  At the end, the work is presented with powerpoint support, with time for further discussion and questions. The work must be presented and written in English. It will also include a quiz about the work presented for the colleagues. A different grade can be assigned to each member of the group. The assessment in classroom includes submiting selected exercises, presented in classroom and solved individually by the student.